#FOLIC SCID PROFESSIONAL#

(More information)ДЇolate is a water-soluble B-vitamin, which is also known as vitamin B 9 or folacin.

Several autosomal recessive disorders affecting folate transport and metabolism can be treated with high doses of folinic acid, a folate derivative. Whether supplemental B-vitamins, including folic acid, will have long-term benefits in maintaining cognitive health is not yet known.

Low folate status and/or high homocysteine concentrations are associated with cognitive dysfunction in aging (from mild impairments to dementia). (More information)ДЇolate is essential for brain development and function. The relationship between folate status and cancer risk is however complex and requires further research.

Prospective cohort studies have reported an inverse association between folate status and colorectal cancer (CRC) risk, especially among men.

However, intervention trials with high doses of folic acid have not generally shown any benefit on cancer incidence. Low folate status has been linked to increased cancer risk. Although folic acid supplementation has been proven effective to control circulating homocysteine concentrations, the effect of homocysteine lowering on the incidence of CVD is still debated. (More information)ДЇolate deficiency and elevated concentrations of homocysteine in the blood are associated with increased risk of cardiovascular disease (CVD). Several studies are currently investigating the role of folic acid supplementation in the prevention of congenital anomalies other than NTDs. Moreover, genetic factors might modify the risk of NTDs by increasing the susceptibility to folate deficiency during pregnancy. Yet, folate status is considered inadequate in a majority of women of childbearing age worldwide. The introduction of mandatory folic acid fortification of refined grain products in the US in 1998 has reduced the prevalence of neural tube defects (NTDs) in newborns. Inadequate folate status during early pregnancy increases the risk of congenital anomalies. (More information)ДЇolate status is influenced by the presence of genetic variations in folate metabolism, particularly those found in the 5,10-methylenetetrahydrofolate reductase ( MTHFR) gene. Improper treatment of vitamin B 12-dependent megaloblastic anemia with high dose supplemental folic acid can potentially delay the diagnosis of vitamin B 12 deficiency and thus leave the individual at risk of developing irreversible brain damage. Severe deficiency in either folate or vitamin B 12 can lead to megaloblastic anemia, which causes fatigue, weakness, and shortness of breath. Folate is critical in the metabolism of nucleic acid precursors and several amino acids, as well as in methylation reactions.

#FOLIC SCID PROFESSIONAL#

Healthcare Professional Continuing EducationДЇolate is a generic term referring to both natural folates in food and folic acid, the synthetic form used in supplements and fortified food.

Chlorophyll and Metallo-Chlorophyll Derivatives.

Folic scid